Last edited by Akinogis
Tuesday, July 28, 2020 | History

3 edition of Cyclic ADP-Ribose and NAADP found in the catalog.

Cyclic ADP-Ribose and NAADP

Structure, Metabolism and Functions

by Hon Cheung Lee

  • 199 Want to read
  • 32 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Pharmacology,
  • Science/Mathematics,
  • Cyclic adenylic acid,
  • Coenzymes,
  • Nucleic Acids,
  • Science,
  • Life Sciences - Biochemistry,
  • Biochemistry,
  • Biotechnology,
  • Medical / Pharmacology,
  • ADP-ribosylation,
  • Calcium channels,
  • Cellular signal transduction,
  • NAD (Coenzyme)

  • The Physical Object
    FormatHardcover
    Number of Pages480
    ID Numbers
    Open LibraryOL8372518M
    ISBN 101402072813
    ISBN 109781402072819

    Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets. Nicotinamide adenine dinucleotide (NAD) metabolites, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP) have been identified as calcium-releasing second messengers. CDcyclic ADP-ribose-mediated calcium signaling in airway myocytes. / Deshpande (NAD) metabolites, cyclic ADP-ribose (cADPR), and Author: Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, Mathur S. Kannan.

    Cyclic ADP-ribose is a newly discovered cyclic nucleotide derived from NAD, but, unlike adenosine 3',5'-cyclic monophosphate, its main signaling function is modulation of Ca(2+)-induced Ca2+ release, a major mechanism of Ca2+ mobilization in addition to the IP3 pathway. Cyclic ADP-ribose (cADPR), a potent Ca 2+ mobilizer from ryanodine-sensitive calcium stores and functionally active in a wide variety of cell types, is generated from NAD + as substrate by a family of multifunctional enzymes designated ADP-ribosyl cyclases (Guse, ; Lee, , ).Two ecto-ADP-ribosyl cyclases have been cloned and characterized: the transmembrane type II glycoprotein CD38 Cited by:

    Here we show that glucose also increases [Ca 2+] i via the novel Ca 2+-mobilizing agent nicotinic acid adenine dinucleotide phosphate (NAADP) in the insulin-secreting β-cell line binds to specific, high-affinity membrane binding sites and at low concentrations elicits robust Ca 2+ responses in intact cells. Higher concentrations of NAADP inactivate NAADP receptors and attenuate the Cited by: Calcium signaling by cyclic ADP-ribose and NAADP. Cell Biochemistry and Biophysics , 28 (1), DOI: /BF Simon M. Fortt, Barry V.L. Potter. An approach to a carbocyclic analogue of cyclic adenosine 5′-diphosphate by:


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Cyclic ADP-Ribose and NAADP by Hon Cheung Lee Download PDF EPUB FB2

Download Citation | Cyclic ADP-Ribose and NAADP | Cells are surrounded by a plasma membrane, which isolates them from the environment and, in so doing, defines their existence.

Internally, cells Author: Hon Cheung Lee. In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers.

About this book Introduction In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers.

A useful property of the sea urchin homogenate system Cyclic ADP-Ribose and NAADP book that Ca2+ release by different Ca2+ mobilizing agents displays homologous desensitization. Both cADPR and NAADP are shown directly to mobilize Ca2+ from intracellular stores in egg homogenates, and by microinjection into intact sea urchin eggs.

cADPR has now been implicated in the regulation of Ca2+ release via RyRs in many different. Description In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP Author: Hon Cheung Lee.

Active Metabolite Inositol Trisphosphate Nicotinic Acid Adenine Dinucleotide Phosphate Fertilization Envelope Cycling Assay These keywords were added by machine and not by the authors.

This process is experimental and the keywords may be updated as the learning algorithm by: Cyclic ADP-ribose and NAADP Cyclic ADP-ribose and NAADP A useful property of the sea urchin homogenate system is that Ca2+release by different Ca2+mobilizing agents Cited by: 1.

The Ca 2ϩ -active products of ADPRCs known so far include cyclic ADP-ribose (cADPR), ADP-ribose (ADPR), nicotinic acid adenine dinucleotide phosphate (NAADP ϩ Author: Hon Cheung Lee.

Title: Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and Cell Function VOLUME: 2 ISSUE: 3 Author(s):Andreas H.

Guse Affiliation:University of Hamburg,University Hospital Hamburg-Eppendorf, Institute for MedicalBiochemistry and Molecular Biology, Div. of Cellular SignalTransduction, Martinistr. 52, D Cited by: Nicotinic acid adenine dinucleotide phosphate, (NAADP), is a Ca 2+-mobilizing second messenger synthesised in response to extracellular its mechanistic cousins, IP 3 and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca 2+ channels on intracellular organelles, thereby increasing the intracellular Ca 2+ concentration which, in turn, modulates sundry CAS Number: DOI.

/B/X. Type. Chapter. Book title. Handbook of Cell Signaling. Publication Date. 07/11/ Volume. Pages. 15 - 17Cited by: 1. In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ by:   Cyclic ADP-Ribose and NAADP and over 8 million other books are available for Amazon Kindle.

£ Cyclic ADP-Ribose and NAADP Paperback – 30 Nov. by Hon Cheung Lee Format: Paperback. Lee HC. Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol. ; – Galione A, Lee HC, Busa WB.

Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science. Sep 6; ()– Lee by: The action of cyclic ADP-ribose in the cell is thought to be similar to that of another signaling molecule, IP3 (see Calcium section).

NADP, the phosphorylated version of NAD, is converted in the cell to nicotinic acid adenine dinucleotide phosphate (NAADP). NAD cannot be used directly for this purpose. Cyclic ADP ribose increased cell proliferation in a concentration-dependent manner and significant effects were observed at concentrations from 10 to 50 μM (Fig.

6A). At 50 μM, the cell proliferation was increased by 19 ± 7% as determined by the MTT by:   Abstract. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two structurally distinct messengers that mobilize the endoplasmic and endolysosomal Ca 2+ stores, respectively.

Both are synthesized by the CD38 molecule (CD38), which has long been thought to be a type II membrane protein whose catalytic domain, intriguingly, faces to the outside of Cited by: 2. Aldebaran M. Hofer, in Cell Physiology Source Book (Fourth Edition), Cyclic ADP-ribose (cADPR) and nicotinic acid-adenine dinucleotide phosphate (NAADP) are related Ca 2+ -mobilizing messengers that are synthesized by a single enzyme (ADP ribosyl cyclase) from NAD + and NADP, respectively.

ISBN: OCLC Number: Description: xviii, pages: illustrations (some color) ; 25 cm: Contents: Cyclic ADP-Ribose and NAADP A Story of Two Calcium Messengers / Lee HC --Ca[superscript 2+] Releasing Effects of NAD and NADP --Cyclic ADP-Ribose (cADPR) --Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) --ADP-Ribosyl Cyclase --CD38.

The NAD+ metabolite cADP-Rib (cADPR) elevates cytosolic free Ca2+ in plants and thereby plays a central role in signal transduction pathways evoked by the drought and stress hormone abscisic acid. cADPR is known to mobilize Ca2+ from the large vacuole of mature cells.

To determine whether additional sites for cADPR-gated Ca2+ release reside in plant cells, microsomes from Cited by:. NAADP; IP3; ADP-ribosa; Ligazóns externas. The web page of Dr. Hon Cheung Lee, the discoverer of cyclic ADP-ribose.

Cyclic ADP-ribose and NAADP. The first book on these two second messengers. Número CAS: Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N 1) of the same adenine base (whose position N 9 has the glycosidic bond to the other ribose) [1] [2].ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: Cyclic ADP-Ribose and NAADP A Story of Two Calcium Messengers --ADP-Ribosyl Cyclases --A Family of cADPR and NAADP Metabolizing Enzymes --Regulation of Synthesis of cADPR and NAADP --A Natural History of the Human CD38 Gene --A .